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Bronchial thermoplasty : ウィキペディア英語版
Bronchial thermoplasty

Bronchial Thermoplasty, delivered by the Alair™ System, is a treatment for severe asthma approved by the FDA in 2010 involving the delivery of controlled, therapeutic radiofrequency energy to the airway wall, thus heating the tissue and reducing the amount of smooth muscle present in the airway wall.〔Cox G., M. D., McWilliams A., FitzGerald J.M., and Lam S. (2006). "Bronchial Thermoplasty for Asthma." ''American Journal of Respiratory Critical Care Medicine'' 173: 965 - 969.〕 This treatment has been shown to result in acute epithelial destruction with regeneration observed in the epithelium, blood vessels, mucosa and nerves. However, airway smooth muscle has demonstrated almost no capacity for regeneration, instead being replaced by connective tissue.〔Mitzner, W. (2006). "Bronchial Thermoplasty in Asthma." ''Allergology International'' 55(3): 225 - 234.〕 The treatment has been shown to be safe and effective over at least five years.〔(【引用サイトリンク】title=DEFINE_ME_WA )
==The Procedure==

A full course of bronchial thermoplasty treatment〔(【引用サイトリンク】title=Clinical Pearls for Bronchial Thermoplasty : Journal of Bronchology & Interventional Pulmonology )〕 includes three separate bronchoscopic procedures: one for the each lower lobe of the lung and another for both upper lobes. Each outpatient procedure is performed approximately three weeks apart.
Under sedation, a catheter inside a bronchoscope—a thin, flexible tube-like instrument introduced through the patient’s nose or mouth, and into their lungs—delivers thermal energy into the airways. The patient is monitored after the procedure and usually returns home that day or early the next day. The catheter delivers a series of 10-second temperature controlled bursts of radio frequency energy which heat the lining of the lungs to 65 degrees Celsius. It is this heat that destroys some of the muscle tissue which constricts during an asthma attack, reducing the number and severity of exacerbations.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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